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Cell Injury Sequelae

  • The basic biochemical mechanisms of cell injury were reviewed in Cell Injury Biochemistry. Cells can survive and recover from mild disturbances in these biochemical processes and when this occurs the cell injury is considered reversible. However, intense derangements in any of these basic biochemical processes often precipitates an irreversible sequence of events which ultimately ends in cell death. Given the inter-connectedness of cellular biochemical processes, severe dysfunction in any one basic process will inevitably cause dysfunction and derangement of the others.Irreversible cell injury can result in cell death through two patterns termed "Necrosis" and "Apoptosis". As discussed in the sections below, these patterns result in different morphological manifestations and are due to distinct molecular mechanisms.