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Chemical Cell Injury

  • A wide variety of chemicals are can induce severe cellular injury. In certain cases the chemical is directly toxic to cellular components such as the plasma membrane or mitochondria, precipitating basic biochemical causes of cell injury (See: Cell Injury Biochemistry). In other cases the chemical is metabolized to a toxic compound, especially by enzymes of hepatic xenobiotic metabolism. Such metabolic manipulations of chemicals often generate reactive intermediates that induce Free Radical Cell Injury (See page).