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Modulation of the Oxygen-Hemoglobin Dissociation Curve |
A variety of environmental factors can shift the Oxygen-Hemoglobin Dissociation Curve. Effects which are associated with increased peripheral tissue metabolism, such as reduced pH, increased CO2, increased temperature, shift the curve to the right, reducing hemoglobinâ€s affinity for oxygen and thus improving oxygen unloading. Chronic hypoxia increases the bloodâ€s concentration of 2,3-DPG which also shifts the curve to the right. The presence of HbF and carbon monoxide (CO) shift the curve to the left, increasing the oxygen affinity of hemoglobin.
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